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| c. 1600 |
| | The Yoruba develop an extensive empire centred on Oyo in southern Nigeria | |
| | Beaded crown of a Yoruba ruler Royal Albert Memorial Museum, Exeter
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| 1603 |
| | Geneva wins independence from the duchy of Savoy, in the treaty of St Julien, after repelling a midnight assault on the city | |
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| 1603 |
| | The accession of James I and VI to the throne of England brings the union of the crowns of England and Scotland | |
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| 1609 |
| | A law is passed expelling the Moriscos from Spain, with the result that some 300,000 are shipped to north Africa | |
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| 1610 |
| | After the assassination of Henry IV, his wife Marie de Médicis becomes regent for the 9-year-old Louis XIII | |
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| 1614 |
| | An edict is passed expelling Jesuit missionaries from Japan, and ordering their converts to revert to Buddhism | |
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| 1616 |
| | Richelieu begins his public career, becoming a secretary of state to Marie de Médicis | |
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| 1620 November 11 |
| | Ten days after their first landfall, at Cape Cod, the adult males on the Mayflower agree a form of government for their new colony | |
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| 1624 |
| | The Japanese are forbidden to leave their country, or foreigners to enter, at the start of more than two centuries of almost total isolation | |
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| c. 1625 |
| | Three brothers among the Dahomey people establish a long-lasting kingdom in the Bight of Benin | |
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